So one of the things that's been joked about is how a whole series of these could exist, most recently on a stream from The Full 42 that Corey Andalora (designer of Explosion in the Laboratory) was on. Explosion in the Laboratory utilizes everything from Fire in the Library in unique, new, inspired ways, and that includes the name!

So, what other terrible events or potential catastrophic events can you tie to locations? Perhaps the Explosion in the Laboratory leads to the Fire in the Library which then leads to the Flood in the Basement where you have to save something else entirely from the basement of the library. Or something else led up to the explosion, like the Dare in the Cafeteria where you up the stakes against one another to come up with the most ridiculous challenge (like, idk, an explosion in a laboratory!)