From the Spirit Island Wiki: Isolate was first introduced in the Jagged Earth expansion as an added effect from certain new Powers, representing a land hard to travel to, from, or through. It prevents Invader Explore Actions, and prevents Invader pieces (Explorer/Town/City) from using adjacencies unless you let them. Isolate is a single-turn effect marker like Defend.
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From the Spirit Island Wiki: Isolate was first introduced in the Jagged Earth expansion as an added effect from certain new Powers, representing a land hard to travel to, from, or through. It prevents Invader Explore Actions, and prevents Invader pieces (Explorer/Town/City) from using adjacencies unless you let them. Isolate is a single-turn effect marker like Defend.